Pearl -Tranexamic Acid (TXA) for the Hemorrhaging Trauma Patient
Early TXA administration has been shown to decrease deaths from acute severe bleeding. It works by inhibiting the breakdown of fibrin thus preserving the clot matrix. A 1g loading dose over 10 mins and another 1g over 8 hrs may reduce mortality.
Coming soon, the CRASH-3 trial, which evaluates its use in patients with TBI. http://crash3.lshtm.ac.uk/
WOMAN - http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)30638-4/fulltext
MATTERs - https://www.ncbi.nlm.nih.gov/pubmed/22006852
CRASH-2 - https://www.ncbi.nlm.nih.gov/pubmed/23477634