Neonates will have physiologically elevated procalcitonin.
Normalizes around 3 days.
Studies show that procalcitonin is useful in detecting/managing sepsis in neonates.
Neonates who have procalcitonin trended seem have shorter duration of antibiotic therapy.
References
Chiesa C, Panero A, Rossi N, Stegagno M, DeGiusti M, Osborn JF, Pacifico L: Reliability of Procalcitonin concentrations for the diagnosis of sepsis in critically ill neonates. Clin Infect Dis. 1998, 26: 664-672. 10.1086/514576.
Stocker, M., Hop, W. C., & van Rossum, A. M. (2010). Neonatal Procalcitonin Intervention Study (NeoPInS): Effect of Procalcitonin-guided decision making on Duration of antibiotic Therapy in suspected neonatal early-onset Sepsis: A multi-centre randomized superiority and non-inferiority Intervention Study. BMC Pediatrics, 10(1).doi:10.1186/1471-2431-10-89
https://www.procalcitonin.com/clinical-utilities/neonatal-sepsis.html