POTD: Tinea Pedis (Athlete's Foot)

This PODT is inspired by a recent case I had in while working in Peds and is something we may encounter often in the summer. This is a perfect example of a fast track compliant that we may have not seen a lot of during COVID.

The patient was a young male in his 20s who works in construction and wears heavy boots and socks for about 8 hours of the day in the heat. He presented with 1 days of sloughing of the skin of both of his feet with discharge.

 Lets discuss Tinea Pedis (Athlete’s Foot):

 Tines pedis is a dermatophyte infection of the skin on the foot.

 Etiology and Risk Factors:

  • Usually occurs in adults and adolescents and is rare prior to puberty

  • Infection is acquired by means of direct contact with the causative organism

  • Commonly seen in patients who have a history of walking barefoot in locker rooms or swimming pool facilities

  • Also commonly seen in patients who wear occlusive footwear

Predisposing factors to consider

  • Diabetes Mellitus

  • Immunodeficiency, Systemic corticosteroid use, or use of immune suppressive agents

  • Poor peripheral circulation or lymphoedema

  • Excessive sweating (hyperhidrosis)

 Who would have know that there are different types of tinea pedis?

  •  Types of Tinea Pedis:

    • Interdigital tinea pedis: Manifests as pruritic erosions or scales between the toes, most commonly in the third and fourth digital interspaces

      • More severe form of this is known as Ulcerative tinea pedis. This is generally associated with secondary bacterial infection

    • Hyperkeratotic (Moccasin-Type): Characterized by diffuse hyperkeratotic eruption involving the soles and medial and lateral surfaces of the feet.    

    • Vesiculobullous (inflammatory-type): Pruritic, sometimes painful, vesicular or bullous eruption. Medial foot often affected 

Management:

  • Topical antifungal therapy is treatment of choice for most patients.

    1. Example of topical antifungal: Azoles, Allylamines, Butenafine, Ciclopirox, Tolnaftate, and Amorolfine. Recommended to apply once or twice a day for four weeks. (Refer to references for dosages and frequency)

    2. Beneficial and more effective for patients to use the suspension formulation of these medications

  • Systemic antifungal agents are primarily reserved for patients who fail topical therapy

    1.   Terbinafine 250mg per day for 2 weeks in adults

      1. Most check LFTs prior to administration and patients need to follow up and have LFTs checked while receiving treatment

      2. Peds dosing:

        • 10 to 20kg: 62.5mg/day

        • 20 to 40kg: 125mg/day

        • Above 40kg: standard adult dosing

    • Itraconazole 200mg per day for two weeks

      •   Peds dosing:

        • 3 to 5 mg/kg per day

    • Fluconazole 150mg once weekly for two to six weeks

      • Peds dosing:

        •   6mg/kg once weekly

  • ·Ulcerative Tinea Pedis;

    •   Always treatment with systemic antifungal agents in addition to topical antifungals

    • Make sure to add in addition to your antifungal an antibiotic such as Keflex

    • Outpatient podiatry follow up should be given to patients

  • Prevention

    • Use of sock with wick-away material

    • Use of desiccating foot powders

    • Tx of hyperhidrosis if there is history of moist feet

    •   Tx of shoes with antifungal powder

    •   Avoidance of occlusive foot wear

 We diagnosed our patient with ulcerative tinea pedis. We started the patient on Terbinafine, Ciclopriox, and Keflex and arranged for podiatry follow up. Our patients case was unique in the fact that the patient had bilateral involvement normally this occurs unilateral.

 References :

·      https://www.uptodate.com/contents/dermatophyte-tinea-infections?search=tinea%20pedis&source=search_result&selectedTitle=1~103&usage_type=default&display_rank=1#H2658711829

·      https://www.uptodate.com/contents/image?csi=18b425c8-5b1f-4694-a039-5bc8aa27c160&source=contentShare&imageKey=PC%2F76148

·      https://wikem.org/wiki/Tinea_pedis

·      https://www.aafp.org/afp/2014/1115/p702.html

·      https://accessemergencymedicine.mhmedical.com/content.aspx?sectionid=109447903&bookid=1658

·      https://dermnetnz.org/topics/tinea-pedis/

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"Six Feet"

Six feet.

I’ve said it. You’ve said it. Fauci has said it. But why are we saying it?

Doesn’t that seem a bit… I don’t know, arbitrary? Random? Other synonyms?

Did you know that the World Health Organization actually recommends one meter?

Can’t germs travel seven feet? Or ten? What about the butterfly effect – if a butterfly sneezes in Taiwan, can’t it infect someone in Madagascar? (Something like that.)

Where did this number come from… (ominous ellipses)

Back in 1942, someone took a “high-speed camera” and photographed respiratory droplets to see if they could travel six feet. They found that most of the droplets fell within 3 feet, which became the party line for social distancing for decades. That’s right – we based social distancing on images from a 1940s camera that photographed spittle drops. 3 feet.

To try and further suss it out, a few bold (?crazy) scientists in the UK opened up the Common Cold Research Unit in 1946. They offered volunteers a 10-day getaway in Salisbury, UK, under one condition… volunteers agreed to be inoculated with the common cold. They suggested in 1947 that the safest distance was 30 feet, though the podcast referenced later here suggests 3ft for large droplets (again). Check out this original publication:

https://journals.sagepub.com/doi/pdf/10.1177/003591574704001104

And a video of their unit from the 50s: https://www.youtube.com/watch?v=SJfBU_MUpI0&feature=emb_logo

In the 1980s through the 2000s, more data (from studies and other outbreaks) came out to suggest not one, but two meters would likely be more effective. So that's where we've stayed...

Fast forward to this year, a systematic review that respiratory droplets often went farther than two meters – like, much farther. Like, 8 meters.

Not only that, but some suggest COVID stays in the air for 16hours! (Though the prevalence and infectivity of these particles is debatable.)

Lots of factors can increase the distance of droplet/particle transmission and it seems that 6 feet may be a bit of an outdated blanket statement. Consider maintaining as much distance as reasonably attainable in your various social situations. Wash your hands, wear a mask, and wear eye protection.

For all you auditory learners, check out this 20min podcast by Radiolab: https://www.wnycstudios.org/podcasts/radiolab/articles/dispatch-4-six-feet

For all you visual learners, below are some fascinating shots of simulated “violent respiratory events” with and without masks, from AIP Physics of Fluids.

(For all you kinesthetic learners, just wear a mask.) 

References:

WHO: who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-publi

CEBM: https://www.cebm.net/covid-19/what-is-the-evidence-to-support-the-2-metre-social-distancing-rule-to-reduce-covid-19-transmission/

Visualizing the Effectiveness of Face Masks in Obstructing Respiratoory Jets: https://aip.scitation.org/doi/10.1063/5.0016018

Radiolab: https://www.wnycstudios.org/podcasts/radiolab/articles/dispatch-4-six-feet

Other references embedded in the the above email

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COPD and antibiotics.

Welcome back to POTD. 

The weekend has come and the weekend has gone. I know you've all been holding your breath to hear about----

A message from our sponsors:

Take a deep inhale. feel some wellness. feel the firmness of your feet on the floor. hold onto your seat.   

Exhale nice and slowly......like someone with a COPD exacerbation.

Because today we're discussing antibiotic coverage in acute COPD Exacerbations. I know you've been waiting a lung time for this one. 

Background

  • Acute COPD exacerbations (AECOPD) account for ~1.5 million ED visits annually in the ED.

  • Many physicians routinely prescribe antibiotic coverage for AECOPD

  • a 2018 review demonstrated antibiotic prescriptions given on 39% of ED visits for AECOPD between 2009-2014.

  • Due to the structural changes in the bronchi of COPD patients they are more prone to bacterial colonization (as opposed to asthmatics - which have no structural change but a reactive process)

Do guidelines exist?

  • Sure do. 

  • if the patient appears infectious (think fever) administer antibiotics. This is understandable given their risk factors and bronchial structural changes.

  • Several guidelines exist for more subtle cases, they exist as follows: (see chart below)

    • Global initiative for Chronic Obstructive Lung Disease:

      • Antibiotics should be given to

        • patients with all 3 of the following cardinal symptom

          1. increased dyspnea

          2. increased sputum volume

          3. increased sputum purulence

        • patients with 2 cardinal symptoms, if there is increased purulence

        • patients requiring noninvasive or invasive ventilation

    • American Thoracic Society/European Respiratory Society

      • hospitalized patients with chanegs in sputum characteristics

      • all patients admitted to an ICU

    • Canadian Thoracic Society

      • patients with severe purulent AECOPD

    • National Institute for Health and Clinical Excellence

      • patients with more purulent sputum

  • Basically, pay attention to that sputum. take a thorough history and discuss changes in sputum production. 

-Elly

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